Lipophilic thiourea and thiouracil as inhibitors of oxidative phosphorylation
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چکیده
منابع مشابه
Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors
Tyrosinase catalyzes two distinct sequential reactions in melanin biosynthesis: The hydroxylation of tyrosine to dihydroxyphenylalanine (DOPA) and the oxidation of DOPA to dopaquinone. Developing functional modulators of tyrosinase is important for therapeutic and cosmetic purposes. Given the abundance of thiourea moiety in known tyrosinase inhibitors, we studied other thiourea-containing drugs...
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N-Alkylation at the ring nitrogen of the D-galactosidase inhibitor 1-deoxygalactonojirimycin with a functionalised C ₆alkyl chain followed by modification with different aromatic substituents provided lipophilic 1-deoxygalactonojirimycin derivatives which exhibit inhibitory properties against β-glycosidases from E. coli and Agrobacterium sp. as well as green coffee bean α-galactosidase. In prel...
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T HE role of the thyroid gland in the regulation of general body metabo, [ism, metamorphosis, growth, and development is well known.The in. fluence of the thyroid gland and its hormone, thyroxine, upon the amount and distribution of body fat is not thoroughly understood. Although obesity is frequently associated with hypothyroidism in the human, this is not always the case and some hypothyroid ...
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متن کاملBarbiturates and oxidative phosphorylation.
It has been claimed that barbiturates uncouple oxidative phosphorylations (Brody & Bain, 1954; Brody, 1955). These authors have demonstrated that during the oxidation of pyruvate by liver and brain mitochondria, phosphate uptake was lowered proportionately more than oxygen uptake. Support for the uncoupling theory was derived from certain similarities between the barbiturates and 2:4dinitrophen...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1976
ISSN: 0014-5793
DOI: 10.1016/0014-5793(76)80173-1